Serpin

Serpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity. Protease inhibition by serpins controls an array of biological processes, including coagulation and inflammation. They are notable for their unusual mechanism of action, in which they irreversibly inhibit their target protease.

About Serpin in brief

Summary SerpinSerpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity. Protease inhibition by serpins controls an array of biological processes, including coagulation and inflammation. They are notable for their unusual mechanism of action, in which they irreversibly inhibit their target protease by undergoing a large conformational change to disrupt its active site. Serpins are vulnerable to mutations that can result in protein misfolding and the formation of inactive long-chain polymers. The term serpin is used to describe these members of the serpin superfamily since they are non-inhibitory, despite their non- enzyme function. Although most serpins control proteolytic cascades, some proteins with a serpin structure are not enzyme inhibitors and instead perform diverse functions such as storage, transport and hormone chaperoning. The acronym serpin was originally coined because the first serpins to be identified act on chymotrypsin-like serine proteases. The proteins are the target of medical research and are of interest to the structural biology and protein folding communities. For more information on serpins, visit: www.serpin-research.org.uk or go to: http://www.

serpin- research.org/index.html/. For more on the role of serpins in the immune system, see:  Serpin Patients and Protective Patient Compliance and Safety (SPC). For more about the role serpins play in the fight against cancer, visit www.siderpin-vaccine.org or visit: Serpin Protease Inhibition Inhibitor (SPI) inhibits Protease inhibition injury in cancer in the vaccine injections and in the treatment of viral tumours and other infections. For a full list of serpin proteases and their activities,  visit:  www.sserpin researchers.org/. For a list of serpin proteins that control coagulation and inflammation, visit: http://sserpins.com/protease-inhibition-inhibiting-pneumonia.html. For an expert on serpins, the University of California, San Diego, California Department of Health and Human Institute of Medicine has published a paper on serpin proteins and their protective properties. For confidential support, call the Samaritans on 1-800-273-8255 or visit the Samaritans  website. For information on how to donate to the Serpin Foundation, visit http://sherpin.org or http www sherpins.org%. For more details on the Serpins Researcher Team, Visit: Serpin Team and the Sherp Receiving Support Online.