Polyethylene glycol
Polyethylene glycol (PEG) is a polyether compound derived from petroleum. PEG is considered biologically inert and safe by the FDA. A growing body of evidence shows the existence of anti-PEG antibodies in approximately 72% of the population. Miralax has not been tested on children.
About Polyethylene glycol in brief
Polyethylene glycol (PEG) is a polyether compound derived from petroleum. PEG is considered biologically inert and safe by the FDA. A growing body of evidence shows the existence of anti-PEG antibodies in approximately 72% of the population, never treated with PEGylated drugs. The FDA has been asked to investigate the possible effects of PEG in laxatives for children. Since 1999, the FDA has received over 1,000 incident reports from parents reporting serious or life threatening side effects after their children were given PEG as an osmotic laxative. Miralax has not been tested on children. Due to its ubiquity in a multitude of products and the large percentage of the.
population with antibodies to PEG, hypersensitive reactions to P EG are an increasing concern. When PEG. is chemically attached to therapeutic molecules, it can sometimes be antigenic, stimulating an anti.PEG antibody response in some patients. Other than these few instances where patients have anti- PEG immune responses, it is generally considered to be a safe component of drug. formulations. It is soluble in water, ethanol, methanol, acetonitrile, dichloromethyl ether and hexane, and is insoluble in diethyl hexane and hydrophobic hexane. It can potentially contain toxic impurities, such as ethylene oxide, 1-dioxane and 1-ethylhexane.
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This page is based on the article Polyethylene glycol published in Wikipedia (as of Dec. 24, 2020) and was automatically summarized using artificial intelligence.
