Milla Jovovich reprises her role as Alice, and is joined by Sienna Guillory as Jill Valentine and Oded Fehr as Carlos Olivera. Paul W. Anderson, the director of the first film, turned down the job due to other commitments. The film borrows elements from several games in the Resident Evil series, such as the characters Valentine and Olivera and the villain Nemesis.
About Resident Evil: Apocalypse in brief

Alice awakens in a deserted hospital and wanders the city in search of supplies, while Umbrella uses the only bridge out of the area to evacuate civilians. Angela Ashford, the daughter of Umbrella researcher Dr. Charles Ashford goes missing after her security car is involved in a collision while being extracted from the city. She is able to take anti-virus serum to prevent turning into a zombie, though she must also take the serum regularly to treat herself with the virus. Alice and the others head to Angela’s location, where they are ambushed by Nemesis, who kills the remaining STARS members before searching for Alice. After being abandoned by their employer following a failed attempt to rescue a civilian, the surviving STARS operatives team up with the surviving civilians to repel zombie attacks. The group continue picking up the rest of the group, picking up stranded civilian L.J. Morales and Terri Morales. They find and rescue Angela, although she reveals that the zombie outbreak is the result of a virus created by her father to treat the genetic disease from which she suffers: only injecting herself with a regularly injecting herself. In response to the virus reaching the bridge, Major Timothy Cain, leader of the Umbrella forces in RaccoON City, seals the exit and forces the residents to return to the city, forcing the residents back to Raccoons City. Valentine kills Wells after he turns into a zombies, but is wounded.
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