Arthrogryposis multiplex congenita
Arthrogryposis, describes congenital joint contracture in two or more areas of the body. Children born with one or more joint contractures have abnormal fibrosis of the muscle tissue causing muscle shortening. The contractures in the joints can result in delayed walking development in the first 5 years.
About Arthrogryposis multiplex congenita in brief
Arthrogryposis, describes congenital joint contracture in two or more areas of the body. Children born with one or more joint contractures have abnormal fibrosis of the muscle tissue causing muscle shortening. The contractures in the joints can result in delayed walking development in the first 5 years, but severity of contractures do not necessarily predict eventual walking ability or inability. The malformations of arthrogyposis can be secondary to environmental factors such as: decreased intrauterine movement, oligohydramnios, and defects in the fetal blood supply. Other causes could be: hyperthermia, limb immobilization and viral infections. Myasthenia gravis of the mother leads also in rare cases to ArthrogRYposis. Research identifying factors of the mutations remains an active area of investigation because identifying these factors could help to develop and develop treatment for the condition. The underlying aetiology and pathogenesis of congenital congenital contractures is still not fully understood. The exact causes of Arthrogeposis are unknown.
In principle: any factor that curtails fetal movement can result in congenitalcontractures. The major cause in humans is fetal akinesia, but this is disputed lately. The most severe forms of the most severe arthrogesis are caused by neurological abnormalities, which can be either genetic or environmental, which is mostly the result of dystrophy, myopathy and mitochondrial dystrophopathy. The condition is not a diagnosis but a clinical finding, so this disease is often accompanied with other syndromes or diseases. There are a few slightly more common diagnoses such as pulmonary hypoplasia, cryptorchidism, congenital heart defects, tracheoesophageal fistulas, inguinal hernias, cleft palate, and eye abnormalities. It is not known how many of these children have an above normal intelligence, and there is no literature available about the cause of this syndrome. There could be also connective tissue, neurological or muscle development disorders. This leads to reduced fetal movement and reduces joint fixation and joint fixation.
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This page is based on the article Arthrogryposis multiplex congenita published in Wikipedia (as of Dec. 05, 2020) and was automatically summarized using artificial intelligence.
